Meaning oftake a run atin English

Verb

1. to attempt or try to achieve; acquire something
   I will take a run at the new project to see if I can lead it.
2. to attack; challenge or confront someone
   The politician's opponent will take a run at her reputation during the debate.
   Synonyms:

   go aftercome atattackassailconfrontchallenge
   Antonyms:

   back offretreatwithdrawsurrenderyield